Reducing Fat Has a Huge Impact!!!

Updated: Oct 16, 2019


Fat intake seems to be much more important for survivors than previously believed. In fact, the greatest benefit was observed in women with early-stage TNBC. Rowan Chlebowski and colleagues found that a low-fat diet reduced death among breast cancer patients by 24%. These results were obtained from post-menopausal women who were followed in the Women's Health Initiative over a period of 5 years. At the San Antonio Breast Cancer Symposium, he announced a 15 year follow-up of these patients which included his subset analysis of TNBC patients. Median survival in the low-fat group was 14 years as opposed to 11.7 years in the control group. This represents a 54% decline in mortality for patients with TNBC. The control group averaged a fat intake of 29.2% of their total calories. Whereas, the low fat group had a fat intake of approximately 20.3% of their total calories.*





*There are 9 kcal per gram of fat. In a 1500 kcal diet, that's 300 fat calories or 33 grams of fat.

The fat content of one hershey bar is 14 g.

Please see the link to caloric recommendations by the USDA based upon gender, age, and activity level.

We're getting closer to understanding the signalling pathways that explain these observations.

A new study out of Heidelberg in the October 23, 2017 edition of News-Medical.net, found that obesity increases metastases. Obesity leads to an increase in the release of cytokines such as leptin and TGF-B, which impair the function of an important component of fatty acid synthesis, ACC1.

Inhibition of ACC1 results in an increase of the fatty acid precursor, Acetyl-CoA. Acetyl-CoA then turns on genes that increase the metastatic ability of cancer cells. Garcia's team also found that by introducing and antibody directed at leptin receptors, metastases were significantly reduced.

Here's a thought, alcohol results in an increased production of Acetyl-CoA and fat. Could this be one of the mechanisms that increases metastases with alcohol use? Please see the Elmhurst site, which depicts the effects of alcohol on metabolism. The red lines denote points in metabolism blocked by alcohol. There's also an interesting summary on Momo-training.

If you're having difficulty finding a diet that works with your lifestyle, you may like the Pegan 365 diet. It incorporates plenty of vegetables and fruits while having little sugar and fat. Yet, it is completely realistic!! See this link from Dr. Oz.


#health #breastcancerrecurrence #15yearfollowupofWHI #earlystagetnbc #fat #lowfatdiet #sanantoniobreastcancersymposium

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